The Ch50 Test: A Comprehensive Analysis


The Ch50 or Complement Test measures the activity of a group of proteins in the bloodstream. These proteins comprise the entire complement system, which is a part of the immune system. The system aids all the antibodies to fight all infections and eliminate substances that are foreign to the body, such as bacteria and viruses.

Besides that, the complement test also determines how autoimmune diseases and other inflammatory conditions function.

When an individual has an autoimmune disease, their body will consider its own tissues as enemies and start fighting through antibodies.

Things to Know About the Complement System

Here are 9 such proteins present in the complement system. They are labelled as C1 to C9. But this system is not as simple as it sounds. Currently, over 60 substances within the immune system mix with the complement proteins once activated.

The overall measurement helps check the activity of the primary complement elements by assessing the entire amount of complement proteins in the blood. One of the most common tests is the ch50 test or the Hemolytic test.

Why Do People Opt for the CH50 or Complement Test?

This test detects autoimmune diseases in the body, such as Lupus. A healthcare professional will utilise the complement test to monitor an individual’s progress in treating an autoimmune disease, such as RA or Rheumatoid Arthritis and SLE or Systemic Lupus.

The test is also utilised for gauging the effectiveness of ongoing treatments for kidney conditions and autoimmune disorders. Besides that, the ch50 test is also helpful in identifying those at high risk of complications in several diseases.

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The Various Types of Complement Tests

An entire measurement will check how exactly the complement system is working. On certain occasions, the physician will order this test for people with a family history of complement deficiency. It is also recommended for individuals who have signs of

  • HUS or Hemolytic Uremic Syndrome
  • RA or Rheumatoid Arthritis
  • SLE or Systematic Lupus
  • Myasthenia Gravis [It’s a neuromuscular disorder]
  • Kidney Disease
  • Cryoglobulinemia [The presence of anomalous proteins in the blood]
  • An Infectious Disease [ Bacteria like Meningitis]

Certain complement tests, such as C4, C3, and C2 tests, will help evaluate the course of specific diseases. Based on your history and symptoms, your physician will recommend a complement measurement, the most targeted test of all three. It’s only the blood draw that is compulsory.

How is the CH50 Test Conducted?

The doctor will conduct the following steps when drawing blood:

  • The doctor will disinfect a specific skin area on your hand or arm.
  • They will take an elastic band and wrap it around your upper arm to let more blood fill the vein.
  • The physician will insert a needle right into the vein and draw out the blood within a small test tube or a vial. You might get a sting or a prick when the needle is inserted into your skin.
  • Once the vial is full, the physician will remove the elastic band along with the needle and then put a small bandage.

You might feel a bit of soreness when the needle is inserted. There will be mild throbbing or bruising once the blood is drawn. But all these things will go away.

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What Does the CH50 Test Outcomes Mean?

When your CH50 test outcomes display less than normal amounts or lessened activity of the complement protein, it means that you might have the following conditions, such as:

  • Malnutrition
  • Lupus
  • Cirrhosis
  • Rheumatoid Arthritis
  • Certain kinds of Kidney Disease
  • Recurrent Infection
  • Hereditary Angioedema [A rare but severe condition of the immune system]
  • When the outcomes show higher than the normal amounts or the increased activity of the complement proteins, this means you will have one of these conditions:
  • Ulcerative Colitis [It’s a condition where the lining of the rectum and large intestine becomes inflamed.]
  • Certain types of cancer, such as Non-Hodgkin Lymphoma or Leukemia

When you’re getting treatment for any autoimmune disease, increased activity or amounts of the complement proteins can indicate that your treatment is working.

Parting Words

The CH50 test can measure the protein’s activity in the body. An experienced healthcare expert conducts it. Before you opt for this test, consult a physician and learn more about it. The doctor will also ask you about any symptoms or signs you’re experiencing and whether you have an autoimmune disease.


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